Impact of macromolecular crowding on DNA replication

Enzymatic activities in vivo occur in a crowded environment composed of many macromolecules. This environment influences DNA replication by increasing the concentration of the constituents, desolvation, decreasing the degrees of freedom for diffusion and hopping of proteins onto DNA, and enhancing b...

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Bibliographic Details
Main Authors: Akabayov, Barak, Akabayov, Sabine R., Lee, Seung–Joo, Wagner, Gerhard, Richardson, Charles C.
Format: Online
Language:English
Published: 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666333/