Genetic Analysis of Primaquine Tolerance in a Patient with Relapsing Vivax Malaria

Patients with Plasmodium vivax malaria are treated with primaquine to prevent relapse infections. We report primaquine failure in a patient with 3 relapses without any possibility of re-infection. Using whole genome sequencing of the relapsing parasite isolates, we identified single nucleotide varia...

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Main Authors:	Bright, A. Taylor, Alenazi, Thamer, Shokoples, Sandra, Tarning, Joel, Paganotti, Giacomo M., White, Nicholas J., Houston, Stanley, Winzeler, Elizabeth A., Yanow, Stephanie K.
Format:	Online
Language:	English
Published:	Centers for Disease Control and Prevention 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647516/

id	pubmed-3647516
recordtype	oai_dc
spelling	pubmed-36475162013-05-14 Genetic Analysis of Primaquine Tolerance in a Patient with Relapsing Vivax Malaria Bright, A. Taylor Alenazi, Thamer Shokoples, Sandra Tarning, Joel Paganotti, Giacomo M. White, Nicholas J. Houston, Stanley Winzeler, Elizabeth A. Yanow, Stephanie K. Dispatch Patients with Plasmodium vivax malaria are treated with primaquine to prevent relapse infections. We report primaquine failure in a patient with 3 relapses without any possibility of re-infection. Using whole genome sequencing of the relapsing parasite isolates, we identified single nucleotide variants as candidate molecular markers of resistance. Centers for Disease Control and Prevention 2013-05 /pmc/articles/PMC3647516/ /pubmed/23648098 http://dx.doi.org/10.3201/eid1905.121852 Text en
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Bright, A. Taylor Alenazi, Thamer Shokoples, Sandra Tarning, Joel Paganotti, Giacomo M. White, Nicholas J. Houston, Stanley Winzeler, Elizabeth A. Yanow, Stephanie K.
spellingShingle	Bright, A. Taylor Alenazi, Thamer Shokoples, Sandra Tarning, Joel Paganotti, Giacomo M. White, Nicholas J. Houston, Stanley Winzeler, Elizabeth A. Yanow, Stephanie K. Genetic Analysis of Primaquine Tolerance in a Patient with Relapsing Vivax Malaria
author_facet	Bright, A. Taylor Alenazi, Thamer Shokoples, Sandra Tarning, Joel Paganotti, Giacomo M. White, Nicholas J. Houston, Stanley Winzeler, Elizabeth A. Yanow, Stephanie K.
author_sort	Bright, A. Taylor
title	Genetic Analysis of Primaquine Tolerance in a Patient with Relapsing Vivax Malaria
title_short	Genetic Analysis of Primaquine Tolerance in a Patient with Relapsing Vivax Malaria
title_full	Genetic Analysis of Primaquine Tolerance in a Patient with Relapsing Vivax Malaria
title_fullStr	Genetic Analysis of Primaquine Tolerance in a Patient with Relapsing Vivax Malaria
title_full_unstemmed	Genetic Analysis of Primaquine Tolerance in a Patient with Relapsing Vivax Malaria
title_sort	genetic analysis of primaquine tolerance in a patient with relapsing vivax malaria
description	Patients with Plasmodium vivax malaria are treated with primaquine to prevent relapse infections. We report primaquine failure in a patient with 3 relapses without any possibility of re-infection. Using whole genome sequencing of the relapsing parasite isolates, we identified single nucleotide variants as candidate molecular markers of resistance.
publisher	Centers for Disease Control and Prevention
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647516/
_version_	1611975965221584896

Genetic Analysis of Primaquine Tolerance in a Patient with Relapsing Vivax Malaria

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