Inhibition of PDE4B suppresses inflammation by increasing expression of the deubiquitinase CYLD
The deubiquitinase CYLD acts as a key negative regulator to tightly control overactive inflammation. Most anti-inflammatory strategies have focused on directly targeting the positive regulator, which often results in significant side effects such as suppression of the host defence response. Here, we...
| Main Authors: | , , , , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Nature Pub. Group
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644066/ |