Tyrosine Kinase Inhibitors Induce Down-Regulation of c-Kit by Targeting the ATP Pocket

Tyrosine Kinase Inhibitors Induce Down-Regulation of c-Kit by Targeting the ATP Pocket

The stem cell factor receptor (SCF) c-Kit plays a pivotal role in regulating cell proliferation and survival in many cell types. In particular, c-Kit is required for early amplification of erythroid progenitors, while it must disappear from cell surface for the cell entering the final steps of matur...

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Bibliographic Details
Main Authors: D'allard, Diane, Gay, Julie, Descarpentries, Clotilde, Frisan, Emilie, Adam, Kevin, Verdier, Frederique, Floquet, Célia, Dubreuil, Patrice, Lacombe, Catherine, Fontenay, Michaela, Mayeux, Patrick, Kosmider, Olivier
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634048/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634048/

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