Differential Adaptation of Candida albicans In Vivo Modulates Immune Recognition by Dectin-1

The β-glucan receptor Dectin-1 is a member of the C-type lectin family and functions as an innate pattern recognition receptor in antifungal immunity. In both mouse and man, Dectin-1 has been found to play an essential role in controlling infections with Candida albicans, a normally commensal fungus...

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Main Authors:	Marakalala, Mohlopheni J., Vautier, Simon, Potrykus, Joanna, Walker, Louise A., Shepardson, Kelly M., Hopke, Alex, Mora-Montes, Hector M., Kerrigan, Ann, Netea, Mihai G., Murray, Graeme I., MacCallum, Donna M., Wheeler, Robert, Munro, Carol A., Gow, Neil A. R., Cramer, Robert A., Brown, Alistair J. P., Brown, Gordon D.
Format:	Online
Language:	English
Published:	Public Library of Science 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630191/

id	pubmed-3630191
recordtype	oai_dc
spelling	pubmed-36301912013-05-01 Differential Adaptation of Candida albicans In Vivo Modulates Immune Recognition by Dectin-1 Marakalala, Mohlopheni J. Vautier, Simon Potrykus, Joanna Walker, Louise A. Shepardson, Kelly M. Hopke, Alex Mora-Montes, Hector M. Kerrigan, Ann Netea, Mihai G. Murray, Graeme I. MacCallum, Donna M. Wheeler, Robert Munro, Carol A. Gow, Neil A. R. Cramer, Robert A. Brown, Alistair J. P. Brown, Gordon D. Research Article The β-glucan receptor Dectin-1 is a member of the C-type lectin family and functions as an innate pattern recognition receptor in antifungal immunity. In both mouse and man, Dectin-1 has been found to play an essential role in controlling infections with Candida albicans, a normally commensal fungus in man which can cause superficial mucocutaneous infections as well as life-threatening invasive diseases. Here, using in vivo models of infection, we show that the requirement for Dectin-1 in the control of systemic Candida albicans infections is fungal strain-specific; a phenotype that only becomes apparent during infection and cannot be recapitulated in vitro. Transcript analysis revealed that this differential requirement for Dectin-1 is due to variable adaptation of C. albicans strains in vivo, and that this results in substantial differences in the composition and nature of their cell walls. In particular, we established that differences in the levels of cell-wall chitin influence the role of Dectin-1, and that these effects can be modulated by antifungal drug treatment. Our results therefore provide substantial new insights into the interaction between C. albicans and the immune system and have significant implications for our understanding of susceptibility and treatment of human infections with this pathogen. Public Library of Science 2013-04-18 /pmc/articles/PMC3630191/ /pubmed/23637604 http://dx.doi.org/10.1371/journal.ppat.1003315 Text en © 2013 Marakalala et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Marakalala, Mohlopheni J. Vautier, Simon Potrykus, Joanna Walker, Louise A. Shepardson, Kelly M. Hopke, Alex Mora-Montes, Hector M. Kerrigan, Ann Netea, Mihai G. Murray, Graeme I. MacCallum, Donna M. Wheeler, Robert Munro, Carol A. Gow, Neil A. R. Cramer, Robert A. Brown, Alistair J. P. Brown, Gordon D.
spellingShingle	Marakalala, Mohlopheni J. Vautier, Simon Potrykus, Joanna Walker, Louise A. Shepardson, Kelly M. Hopke, Alex Mora-Montes, Hector M. Kerrigan, Ann Netea, Mihai G. Murray, Graeme I. MacCallum, Donna M. Wheeler, Robert Munro, Carol A. Gow, Neil A. R. Cramer, Robert A. Brown, Alistair J. P. Brown, Gordon D. Differential Adaptation of Candida albicans In Vivo Modulates Immune Recognition by Dectin-1
author_facet	Marakalala, Mohlopheni J. Vautier, Simon Potrykus, Joanna Walker, Louise A. Shepardson, Kelly M. Hopke, Alex Mora-Montes, Hector M. Kerrigan, Ann Netea, Mihai G. Murray, Graeme I. MacCallum, Donna M. Wheeler, Robert Munro, Carol A. Gow, Neil A. R. Cramer, Robert A. Brown, Alistair J. P. Brown, Gordon D.
author_sort	Marakalala, Mohlopheni J.
title	Differential Adaptation of Candida albicans In Vivo Modulates Immune Recognition by Dectin-1
title_short	Differential Adaptation of Candida albicans In Vivo Modulates Immune Recognition by Dectin-1
title_full	Differential Adaptation of Candida albicans In Vivo Modulates Immune Recognition by Dectin-1
title_fullStr	Differential Adaptation of Candida albicans In Vivo Modulates Immune Recognition by Dectin-1
title_full_unstemmed	Differential Adaptation of Candida albicans In Vivo Modulates Immune Recognition by Dectin-1
title_sort	differential adaptation of candida albicans in vivo modulates immune recognition by dectin-1
description	The β-glucan receptor Dectin-1 is a member of the C-type lectin family and functions as an innate pattern recognition receptor in antifungal immunity. In both mouse and man, Dectin-1 has been found to play an essential role in controlling infections with Candida albicans, a normally commensal fungus in man which can cause superficial mucocutaneous infections as well as life-threatening invasive diseases. Here, using in vivo models of infection, we show that the requirement for Dectin-1 in the control of systemic Candida albicans infections is fungal strain-specific; a phenotype that only becomes apparent during infection and cannot be recapitulated in vitro. Transcript analysis revealed that this differential requirement for Dectin-1 is due to variable adaptation of C. albicans strains in vivo, and that this results in substantial differences in the composition and nature of their cell walls. In particular, we established that differences in the levels of cell-wall chitin influence the role of Dectin-1, and that these effects can be modulated by antifungal drug treatment. Our results therefore provide substantial new insights into the interaction between C. albicans and the immune system and have significant implications for our understanding of susceptibility and treatment of human infections with this pathogen.
publisher	Public Library of Science
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630191/
_version_	1611971229984489472

Differential Adaptation of Candida albicans In Vivo Modulates Immune Recognition by Dectin-1

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