Targeting endothelial CD146 attenuates neuroinflammation by limiting lymphocyte extravasation to the CNS

Targeting endothelial CD146 attenuates neuroinflammation by limiting lymphocyte extravasation to the CNS

The ability to selectively block the entry of leukocytes into the central nervous system (CNS) without compromising the immune system is an attractive therapeutic approach for treating multiple sclerosis (MS). Using endothelial CD146-deficienct mice as a MS model, we found that endothelial CD146 pla...

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Bibliographic Details
Main Authors: Duan, Hongxia, Xing, Shu, Luo, Yongting, Feng, Liqun, Gramaglia, Irene, Zhang, Ying, Lu, Di, Zeng, Qiqun, Fan, Kelong, Feng, Jing, Yang, Dongling, Qin, Zhihai, Couraud, Pierre-Olivier, Romero, Ignacio A., Weksler, Babette, Yan, Xiyun
Format: Online
Language:English
Published: Nature Publishing Group 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629416/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629416/

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