Sulfhydration mediates neuroprotective actions of parkin
Increases in S-nitrosylation and inactivation of the neuroprotective ubiquitin E3 ligase, parkin, in the brains of patients with Parkinson’s Disease (PD) are thought to be pathogenic and suggest a possible mechanism linking parkin to sporadic PD. Here we demonstrate that physiologic modification of...
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| Format: | Online |
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2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622945/ |
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pubmed-36229452013-09-27 Sulfhydration mediates neuroprotective actions of parkin Vandiver, M. Scott Paul, Bindu D. Xu, Risheng Karuppagounder, Senthilkumar Rao, Feng Snowman, Adele M. Ko, Han Seok Lee, Yun Il Dawson, Valina L. Dawson, Ted M. Sen, Nilkantha Snyder, Solomon H. Article Increases in S-nitrosylation and inactivation of the neuroprotective ubiquitin E3 ligase, parkin, in the brains of patients with Parkinson’s Disease (PD) are thought to be pathogenic and suggest a possible mechanism linking parkin to sporadic PD. Here we demonstrate that physiologic modification of parkin by hydrogen sulfide (H2S), termed sulfhydration, enhances its catalytic activity. Sulfhydration sites are identified by mass spectrometry analysis and investigated by site directed mutagenesis. Parkin sulfhydration is markedly depleted in the brains of patients with PD, suggesting that this loss may be pathologic. This implies that H2S donors may be therapeutic. 2013 /pmc/articles/PMC3622945/ /pubmed/23535647 http://dx.doi.org/10.1038/ncomms2623 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Vandiver, M. Scott Paul, Bindu D. Xu, Risheng Karuppagounder, Senthilkumar Rao, Feng Snowman, Adele M. Ko, Han Seok Lee, Yun Il Dawson, Valina L. Dawson, Ted M. Sen, Nilkantha Snyder, Solomon H. |
| spellingShingle |
Vandiver, M. Scott Paul, Bindu D. Xu, Risheng Karuppagounder, Senthilkumar Rao, Feng Snowman, Adele M. Ko, Han Seok Lee, Yun Il Dawson, Valina L. Dawson, Ted M. Sen, Nilkantha Snyder, Solomon H. Sulfhydration mediates neuroprotective actions of parkin |
| author_facet |
Vandiver, M. Scott Paul, Bindu D. Xu, Risheng Karuppagounder, Senthilkumar Rao, Feng Snowman, Adele M. Ko, Han Seok Lee, Yun Il Dawson, Valina L. Dawson, Ted M. Sen, Nilkantha Snyder, Solomon H. |
| author_sort |
Vandiver, M. Scott |
| title |
Sulfhydration mediates neuroprotective actions of parkin |
| title_short |
Sulfhydration mediates neuroprotective actions of parkin |
| title_full |
Sulfhydration mediates neuroprotective actions of parkin |
| title_fullStr |
Sulfhydration mediates neuroprotective actions of parkin |
| title_full_unstemmed |
Sulfhydration mediates neuroprotective actions of parkin |
| title_sort |
sulfhydration mediates neuroprotective actions of parkin |
| description |
Increases in S-nitrosylation and inactivation of the neuroprotective ubiquitin E3 ligase, parkin, in the brains of patients with Parkinson’s Disease (PD) are thought to be pathogenic and suggest a possible mechanism linking parkin to sporadic PD. Here we demonstrate that physiologic modification of parkin by hydrogen sulfide (H2S), termed sulfhydration, enhances its catalytic activity. Sulfhydration sites are identified by mass spectrometry analysis and investigated by site directed mutagenesis. Parkin sulfhydration is markedly depleted in the brains of patients with PD, suggesting that this loss may be pathologic. This implies that H2S donors may be therapeutic. |
| publishDate |
2013 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622945/ |
| _version_ |
1611969377086734336 |