Genetic Surveillance Detects Both Clonal and Epidemic Transmission of Malaria following Enhanced Intervention in Senegal
Using parasite genotyping tools, we screened patients with mild uncomplicated malaria seeking treatment at a clinic in Thiès, Senegal, from 2006 to 2011. We identified a growing frequency of infections caused by genetically identical parasite strains, coincident with increased deployment of malaria...
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Public Library of Science
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617153/ |
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pubmed-3617153 |
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pubmed-36171532013-04-16 Genetic Surveillance Detects Both Clonal and Epidemic Transmission of Malaria following Enhanced Intervention in Senegal Daniels, Rachel Chang, Hsiao-Han Séne, Papa Diogoye Park, Danny C. Neafsey, Daniel E. Schaffner, Stephen F. Hamilton, Elizabeth J. Lukens, Amanda K. Van Tyne, Daria Mboup, Souleymane Sabeti, Pardis C. Ndiaye, Daouda Wirth, Dyann F. Hartl, Daniel L. Volkman, Sarah K. Research Article Using parasite genotyping tools, we screened patients with mild uncomplicated malaria seeking treatment at a clinic in Thiès, Senegal, from 2006 to 2011. We identified a growing frequency of infections caused by genetically identical parasite strains, coincident with increased deployment of malaria control interventions and decreased malaria deaths. Parasite genotypes in some cases persisted clonally across dry seasons. The increase in frequency of genetically identical parasite strains corresponded with decrease in the probability of multiple infections. Further, these observations support evidence of both clonal and epidemic population structures. These data provide the first evidence of a temporal correlation between the appearance of identical parasite types and increased malaria control efforts in Africa, which here included distribution of insecticide treated nets (ITNs), use of rapid diagnostic tests (RDTs) for malaria detection, and deployment of artemisinin combination therapy (ACT). Our results imply that genetic surveillance can be used to evaluate the effectiveness of disease control strategies and assist a rational global malaria eradication campaign. Public Library of Science 2013-04-04 /pmc/articles/PMC3617153/ /pubmed/23593309 http://dx.doi.org/10.1371/journal.pone.0060780 Text en © 2013 Daniels et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Daniels, Rachel Chang, Hsiao-Han Séne, Papa Diogoye Park, Danny C. Neafsey, Daniel E. Schaffner, Stephen F. Hamilton, Elizabeth J. Lukens, Amanda K. Van Tyne, Daria Mboup, Souleymane Sabeti, Pardis C. Ndiaye, Daouda Wirth, Dyann F. Hartl, Daniel L. Volkman, Sarah K. |
| spellingShingle |
Daniels, Rachel Chang, Hsiao-Han Séne, Papa Diogoye Park, Danny C. Neafsey, Daniel E. Schaffner, Stephen F. Hamilton, Elizabeth J. Lukens, Amanda K. Van Tyne, Daria Mboup, Souleymane Sabeti, Pardis C. Ndiaye, Daouda Wirth, Dyann F. Hartl, Daniel L. Volkman, Sarah K. Genetic Surveillance Detects Both Clonal and Epidemic Transmission of Malaria following Enhanced Intervention in Senegal |
| author_facet |
Daniels, Rachel Chang, Hsiao-Han Séne, Papa Diogoye Park, Danny C. Neafsey, Daniel E. Schaffner, Stephen F. Hamilton, Elizabeth J. Lukens, Amanda K. Van Tyne, Daria Mboup, Souleymane Sabeti, Pardis C. Ndiaye, Daouda Wirth, Dyann F. Hartl, Daniel L. Volkman, Sarah K. |
| author_sort |
Daniels, Rachel |
| title |
Genetic Surveillance Detects Both Clonal and Epidemic Transmission of Malaria following Enhanced Intervention in Senegal |
| title_short |
Genetic Surveillance Detects Both Clonal and Epidemic Transmission of Malaria following Enhanced Intervention in Senegal |
| title_full |
Genetic Surveillance Detects Both Clonal and Epidemic Transmission of Malaria following Enhanced Intervention in Senegal |
| title_fullStr |
Genetic Surveillance Detects Both Clonal and Epidemic Transmission of Malaria following Enhanced Intervention in Senegal |
| title_full_unstemmed |
Genetic Surveillance Detects Both Clonal and Epidemic Transmission of Malaria following Enhanced Intervention in Senegal |
| title_sort |
genetic surveillance detects both clonal and epidemic transmission of malaria following enhanced intervention in senegal |
| description |
Using parasite genotyping tools, we screened patients with mild uncomplicated malaria seeking treatment at a clinic in Thiès, Senegal, from 2006 to 2011. We identified a growing frequency of infections caused by genetically identical parasite strains, coincident with increased deployment of malaria control interventions and decreased malaria deaths. Parasite genotypes in some cases persisted clonally across dry seasons. The increase in frequency of genetically identical parasite strains corresponded with decrease in the probability of multiple infections. Further, these observations support evidence of both clonal and epidemic population structures. These data provide the first evidence of a temporal correlation between the appearance of identical parasite types and increased malaria control efforts in Africa, which here included distribution of insecticide treated nets (ITNs), use of rapid diagnostic tests (RDTs) for malaria detection, and deployment of artemisinin combination therapy (ACT). Our results imply that genetic surveillance can be used to evaluate the effectiveness of disease control strategies and assist a rational global malaria eradication campaign. |
| publisher |
Public Library of Science |
| publishDate |
2013 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617153/ |
| _version_ |
1611967786876141568 |