Physiological release of endogenous tau is stimulated by neuronal activity

This report provides evidence that stimulation of neuronal activity, or AMPA receptor activation, induces tau release from cortical neurons via a calcium-dependent mechanism. Dysregulation of this process could lead to the spread of tau pathology in disease.

Bibliographic Details
Main Authors:	Pooler, Amy M, Phillips, Emma C, Lau, Dawn H W, Noble, Wendy, Hanger, Diane P
Format:	Online
Language:	English
Published:	Nature Publishing Group 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615658/

id	pubmed-3615658
recordtype	oai_dc
spelling	pubmed-36156582013-04-04 Physiological release of endogenous tau is stimulated by neuronal activity Pooler, Amy M Phillips, Emma C Lau, Dawn H W Noble, Wendy Hanger, Diane P Scientific Reports This report provides evidence that stimulation of neuronal activity, or AMPA receptor activation, induces tau release from cortical neurons via a calcium-dependent mechanism. Dysregulation of this process could lead to the spread of tau pathology in disease. Nature Publishing Group 2013-04 2013-02-15 /pmc/articles/PMC3615658/ /pubmed/23412472 http://dx.doi.org/10.1038/embor.2013.15 Text en Copyright © 2013, European Molecular Biology Organization http://creativecommons.org/licenses/by-nc-sa/3.0/ This article is licensed under a Creative Commons Attribution Noncommercial Share Alike 3.0 Unported License.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Pooler, Amy M Phillips, Emma C Lau, Dawn H W Noble, Wendy Hanger, Diane P
spellingShingle	Pooler, Amy M Phillips, Emma C Lau, Dawn H W Noble, Wendy Hanger, Diane P Physiological release of endogenous tau is stimulated by neuronal activity
author_facet	Pooler, Amy M Phillips, Emma C Lau, Dawn H W Noble, Wendy Hanger, Diane P
author_sort	Pooler, Amy M
title	Physiological release of endogenous tau is stimulated by neuronal activity
title_short	Physiological release of endogenous tau is stimulated by neuronal activity
title_full	Physiological release of endogenous tau is stimulated by neuronal activity
title_fullStr	Physiological release of endogenous tau is stimulated by neuronal activity
title_full_unstemmed	Physiological release of endogenous tau is stimulated by neuronal activity
title_sort	physiological release of endogenous tau is stimulated by neuronal activity
description	This report provides evidence that stimulation of neuronal activity, or AMPA receptor activation, induces tau release from cortical neurons via a calcium-dependent mechanism. Dysregulation of this process could lead to the spread of tau pathology in disease.
publisher	Nature Publishing Group
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615658/
_version_	1611967319578247168

Physiological release of endogenous tau is stimulated by neuronal activity

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