Physiological release of endogenous tau is stimulated by neuronal activity
This report provides evidence that stimulation of neuronal activity, or AMPA receptor activation, induces tau release from cortical neurons via a calcium-dependent mechanism. Dysregulation of this process could lead to the spread of tau pathology in disease.
| Main Authors: | , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Nature Publishing Group
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615658/ |