Allostery and instability in the functional plasticity of synaptotagmin I

Synaptotagmin I (Syt I) is the calcium ion sensor for regulated release of neurotransmitter. How Syt I mediates this cellular event has been a question of extensive study for decades and yet, a clear understanding of the protein’s diverse functionality has remained elusive. Using tools of thermodyna...

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Main Authors:	Fealey, Michael E., Hinderliter, Anne
Format:	Online
Language:	English
Published:	Landes Bioscience 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609835/

id	pubmed-3609835
recordtype	oai_dc
spelling	pubmed-36098352013-06-07 Allostery and instability in the functional plasticity of synaptotagmin I Fealey, Michael E. Hinderliter, Anne Article Addendum Synaptotagmin I (Syt I) is the calcium ion sensor for regulated release of neurotransmitter. How Syt I mediates this cellular event has been a question of extensive study for decades and yet, a clear understanding of the protein’s diverse functionality has remained elusive. Using tools of thermodynamics, we have identified two intrinsic properties that may account for Syt I’s functional plasticity: marginal stability and negative coupling. These two intrinsic properties have the potential to provide great conformational flexibility and suggest that Syt I’s functional plasticity stems in part from subtle rearrangements in the protein’s conformational ensemble. This model for Syt I function is discussed within the context of the nervous system’s overall plasticity. Landes Bioscience 2013-03-01 2013-03-01 /pmc/articles/PMC3609835/ /pubmed/23750295 http://dx.doi.org/10.4161/cib.22830 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Fealey, Michael E. Hinderliter, Anne
spellingShingle	Fealey, Michael E. Hinderliter, Anne Allostery and instability in the functional plasticity of synaptotagmin I
author_facet	Fealey, Michael E. Hinderliter, Anne
author_sort	Fealey, Michael E.
title	Allostery and instability in the functional plasticity of synaptotagmin I
title_short	Allostery and instability in the functional plasticity of synaptotagmin I
title_full	Allostery and instability in the functional plasticity of synaptotagmin I
title_fullStr	Allostery and instability in the functional plasticity of synaptotagmin I
title_full_unstemmed	Allostery and instability in the functional plasticity of synaptotagmin I
title_sort	allostery and instability in the functional plasticity of synaptotagmin i
description	Synaptotagmin I (Syt I) is the calcium ion sensor for regulated release of neurotransmitter. How Syt I mediates this cellular event has been a question of extensive study for decades and yet, a clear understanding of the protein’s diverse functionality has remained elusive. Using tools of thermodynamics, we have identified two intrinsic properties that may account for Syt I’s functional plasticity: marginal stability and negative coupling. These two intrinsic properties have the potential to provide great conformational flexibility and suggest that Syt I’s functional plasticity stems in part from subtle rearrangements in the protein’s conformational ensemble. This model for Syt I function is discussed within the context of the nervous system’s overall plasticity.
publisher	Landes Bioscience
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609835/
_version_	1611965775487172608

Allostery and instability in the functional plasticity of synaptotagmin I

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