NODAL and SHH dose-dependent double inhibition promotes an HPE-like phenotype in chick embryos
Holoprosencephaly (HPE) is a common congenital defect that results from failed or incomplete forebrain cleavage. HPE is characterized by a wide clinical spectrum, with inter- and intrafamilial variability. This heterogeneity is not well understood and it has been suggested that HPE involves a combin...
| Main Authors: | , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
The Company of Biologists Limited
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597036/ |