Systematic repression of transcription factors reveals limited patterns of gene expression changes in ES cells

Systematic repression of transcription factors reveals limited patterns of gene expression changes in ES cells

Networks of transcription factors (TFs) are thought to determine and maintain the identity of cells. Here we systematically repressed each of 100 TFs with shRNA and carried out global gene expression profiling in mouse embryonic stem (ES) cells. Unexpectedly, only the repression of a handful of TFs...

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Bibliographic Details
Main Authors: Nishiyama, Akira, Sharov, Alexei A., Piao, Yulan, Amano, Misa, Amano, Tomokazu, Hoang, Hien G., Binder, Bernard Y., Tapnio, Richard, Bassey, Uwem, Malinou, Justin N., Correa-Cerro, Lina S., Yu, Hong, Xin, Li, Meyers, Emily, Zalzman, Michal, Nakatake, Yuhki, Stagg, Carole, Sharova, Lioudmila, Qian, Yong, Dudekula, Dawood, Sheer, Sarah, Cadet, Jean S., Hirata, Tetsuya, Yang, Hsih-Te, Goldberg, Ilya, Evans, Michele K., Longo, Dan L., Schlessinger, David, Ko, Minoru S. H.
Format: Online
Language:English
Published: Nature Publishing Group 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589720/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589720/

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