Nuclear Translocation of Cardiac G Protein-Coupled Receptor Kinase 5 Downstream of Select Gq-Activating Hypertrophic Ligands Is a Calmodulin-Dependent Process

Nuclear Translocation of Cardiac G Protein-Coupled Receptor Kinase 5 Downstream of Select Gq-Activating Hypertrophic Ligands Is a Calmodulin-Dependent Process

G protein-Coupled Receptors (GPCRs) kinases (GRKs) play a crucial role in regulating cardiac hypertrophy. Recent data from our lab has shown that, following ventricular pressure overload, GRK5, a primary cardiac GRK, facilitates maladaptive myocyte growth via novel nuclear localization. In the nucle...

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Bibliographic Details
Main Authors: Gold, Jessica I., Martini, Jeffrey S., Hullmann, Jonathan, Gao, Erhe, Chuprun, J. Kurt, Lee, Linda, Tilley, Douglas G., Rabinowitz, Joseph E., Bossuyt, Julie, Bers, Donald M., Koch, Walter J.
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589474/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589474/

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