Quantitative properties and receptor reserve of the IP3 and calcium branch of Gq-coupled receptor signaling
Gq-coupled plasma membrane receptors activate phospholipase C (PLC), which hydrolyzes membrane phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). This leads to calcium release, protein kinase C (PKC) activation, and so...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
The Rockefeller University Press
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639578/ |