Conditional Inactivation of the DNA Damage Response Gene Hus1 in Mouse Testis Reveals Separable Roles for Components of the RAD9-RAD1-HUS1 Complex in Meiotic Chromosome Maintenance

Conditional Inactivation of the DNA Damage Response Gene Hus1 in Mouse Testis Reveals Separable Roles for Components of the RAD9-RAD1-HUS1 Complex in Meiotic Chromosome Maintenance

The RAD9-RAD1-HUS1 (9-1-1) complex is a heterotrimeric PCNA-like clamp that responds to DNA damage in somatic cells by promoting DNA repair as well as ATR-dependent DNA damage checkpoint signaling. In yeast, worms, and flies, the 9-1-1 complex is also required for meiotic checkpoint function and eff...

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Bibliographic Details
Main Authors: Lyndaker, Amy M., Lim, Pei Xin, Mleczko, Joanna M., Diggins, Catherine E., Holloway, J. Kim, Holmes, Rebecca J., Kan, Rui, Schlafer, Donald H., Freire, Raimundo, Cohen, Paula E., Weiss, Robert S.
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585019/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585019/

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