Cell type and context-specific function of PLAG1 for IGF2 P3 promoter activity

The fetal transcription factor PLAG1 is found to be overexpressed in cancers, and has been suggested to bind the insulin like growth factor 2 (IGF2) P3 promoter, and to activate the IGF2 gene. The expression of IGF2 has partly been linked to loss of CTCF-dependent chromatin insulator function at the...

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Bibliographic Details
Main Authors: AKHTAR, MONIRA, HOLMGREN, CLAES, GÖNDÖR, ANITA, VESTERLUND, MATTIAS, KANDURI, CHANDRASEKHAR, LARSSON, CATHARINA, EKSTRÖM, TOMAS J.
Format: Online
Language:English
Published: D.A. Spandidos 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583874/