Recognition of lipid A variants by the TLR4-MD-2 receptor complex
Lipopolysaccharide (LPS) is a component of the outer membrane of almost all Gram-negative bacteria and consists of lipid A, core sugars, and O-antigen. LPS is recognized by Toll-like receptor 4 (TLR4) and MD-2 on host innate immune cells and can signal to activate the transcription factor NFκB, lead...
| Main Authors: | , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Frontiers Media S.A.
2013
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569842/ |