Tandem aldehyde–alkyne–amine coupling/cycloisomerization: A new synthesis of coumarins
Cu-catalyzed A3 coupling of ethoxyacetylene, pyrrolidine and salicylaldehydes led to a concomitant cycloisomerization followed by hydrolysis of the resultant vinyl ether to afford coumarins in a cascade process. The reaction proceeded through exclusive 6-endo-dig cyclization and is compatible with h...
| Main Authors: | , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Beilstein-Institut
2013
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566765/ |