A gold-catalyzed alkyne-diol cycloisomerization for the synthesis of oxygenated 5,5-spiroketals
A highly efficient synthesis of oxygenated 5,5-spiroketals was performed towards the synthesis of the cephalosporolides. Gold(I) chloride in methanol induced the cycloisomerization of a protected alkyne triol with concomitant deprotection to give a strategically hydroxylated 5,5-spiroketal, despite...
| Main Authors: | , |
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| Format: | Online |
| Language: | English |
| Published: |
Beilstein-Institut
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107449/ |