Vitamin E δ-Tocotrienol Induces p27Kip1-Dependent Cell-Cycle Arrest in Pancreatic Cancer Cells via an E2F-1-Dependent Mechanism

Vitamin E δ-Tocotrienol Induces p27Kip1-Dependent Cell-Cycle Arrest in Pancreatic Cancer Cells via an E2F-1-Dependent Mechanism

Vitamin E δ-tocotrienol has been shown to have antitumor activity, but the precise molecular mechanism by which it inhibits the proliferation of cancer cells remains unclear. Here, we demonstrated that δ-tocotrienol exerted significant cell growth inhibition pancreatic ductal cancer (PDCA) cells wit...

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Bibliographic Details
Main Authors: Hodul, Pamela J., Dong, Yanbin, Husain, Kazim, Pimiento, Jose M., Chen, Jiandong, Zhang, Anying, Francois, Rony, Pledger, Warren J., Coppola, Domenico, Sebti, Said M., Chen, Dung-Tsa, Malafa, Mokenge P.
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564846/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564846/

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