A Phase I Safety, Pharmacokinetic, and Pharmacodynamic Presurgical Trial of Vitamin E δ-tocotrienol in Patients with Pancreatic Ductal Neoplasia

A Phase I Safety, Pharmacokinetic, and Pharmacodynamic Presurgical Trial of Vitamin E δ-tocotrienol in Patients with Pancreatic Ductal Neoplasia

•Vitamin E δ-tocotrienol is the bioactive form of one of the natural vitamin E with activity against cancer cells•Vitamin E δ-tocotrienol is safe in patients up to 3200 mg•Vitamin E δ-tocotrienol selectively kills pancreatic tumor cells when compared with normal cells at 400, 600, and 800 mg/day•The...

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Bibliographic Details
Main Authors: Springett, Gregory M., Husain, Kazim, Neuger, Anthony, Centeno, Barbara, Chen, Dung-Tsa, Hutchinson, Tai Z., Lush, Richard M., Sebti, Saïd, Malafa, Mokenge P.
Format: Online
Language:English
Published: Elsevier 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703733/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703733/

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