Rapamycin and mTOR: a serendipitous discovery and implications for breast cancer
Rapamycin was discovered more than thirty years ago from a soil sample from the island of Rapa Nui. It was isolated from Streptomyces hygroscopicus and initial characterization focused on its antifungal activities. Subsequent characterization showed that it has immunosuppressive properties and has b...
Main Author: | Seto, Belinda |
---|---|
Format: | Online |
Language: | English |
Published: |
Springer
2012
|
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561035/ |
Similar Items
-
Phosphorylated Mammalian Target of Rapamycin p-mTOR Is a Favorable Prognostic Factor than mTOR in Gastric Cancer
by: Cao, Guo-dong, et al.
Published: (2016) -
On the Discovery of TOR As the Target of Rapamycin
by: Heitman, Joseph
Published: (2015) -
Serendipitous discoveries in microarray analysis
by: Ellingson, Sally R, et al.
Published: (2010) -
The mTOR Inhibitor Rapamycin Has Limited Acute Anticonvulsant Effects in Mice
by: Hartman, Adam L., et al.
Published: (2012) -
The Role of Mechanistic Target of Rapamycin (mTOR) Complexes Signaling in the Immune Responses
by: Soliman, Ghada A.
Published: (2013)