Point Mutations in FimH Adhesin of Crohn's Disease-Associated Adherent-Invasive Escherichia coli Enhance Intestinal Inflammatory Response

Point Mutations in FimH Adhesin of Crohn's Disease-Associated Adherent-Invasive Escherichia coli Enhance Intestinal Inflammatory Response

Adherent-invasive Escherichia coli (AIEC) are abnormally predominant on Crohn's disease (CD) ileal mucosa. AIEC reference strain LF82 adheres to ileal enterocytes via the common type 1 pili adhesin FimH and recognizes CEACAM6 receptors abnormally expressed on CD ileal epithelial cells. The fimH...

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Bibliographic Details
Main Authors: Dreux, Nicolas, Denizot, Jérémy, Martinez-Medina, Margarita, Mellmann, Alexander, Billig, Maria, Kisiela, Dagmara, Chattopadhyay, Sujay, Sokurenko, Evgeni, Neut, Christel, Gower-Rousseau, Corinne, Colombel, Jean-Frédéric, Bonnet, Richard, Darfeuille-Michaud, Arlette, Barnich, Nicolas
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554634/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554634/

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