Pharmacokinetics and Pharmacodynamics of the Proton Pump Inhibitors
Proton pump inhibitor (PPI) is a prodrug which is activated by acid. Activated PPI binds covalently to the gastric H+, K+-ATPase via disulfide bond. Cys813 is the primary site responsible for the inhibition of acid pump enzyme, where PPIs bind. Omeprazole was the first PPI introduced in market, foll...
| Main Authors: | , |
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| Format: | Online |
| Language: | English |
| Published: |
Korean Society of Neurogastroenterology and Motility
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548122/ |