How helminths use excretory secretory fractions to modulate dendritic cells
It is well known that helminth parasites have immunomodulatory effects on their hosts. They characteristically cause a skew toward TH2 immunity, stimulate Treg cells while simultaneously inhibiting TH1 and TH17 responses. Additionally, they induce eosinophilia and extensive IgE release. The exact me...
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| Format: | Online |
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Landes Bioscience
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545949/ |
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pubmed-35459492013-01-18 How helminths use excretory secretory fractions to modulate dendritic cells White, Rhiannon R. Artavanis-Tsakonas, Katerina Review It is well known that helminth parasites have immunomodulatory effects on their hosts. They characteristically cause a skew toward TH2 immunity, stimulate Treg cells while simultaneously inhibiting TH1 and TH17 responses. Additionally, they induce eosinophilia and extensive IgE release. The exact mechanism of how the worms achieve this effect have yet to be fully elucidated; however, parasite-derived secretions and their interaction with antigen presenting cells have been centrally implicated. Herein, we will review the effects of helminth excretory-secretory fractions on dendritic cells and discuss how this interaction is crucial in shaping the host response. Landes Bioscience 2012-11-15 /pmc/articles/PMC3545949/ /pubmed/23221477 http://dx.doi.org/10.4161/viru.22832 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
White, Rhiannon R. Artavanis-Tsakonas, Katerina |
| spellingShingle |
White, Rhiannon R. Artavanis-Tsakonas, Katerina How helminths use excretory secretory fractions to modulate dendritic cells |
| author_facet |
White, Rhiannon R. Artavanis-Tsakonas, Katerina |
| author_sort |
White, Rhiannon R. |
| title |
How helminths use excretory secretory fractions to modulate dendritic cells |
| title_short |
How helminths use excretory secretory fractions to modulate dendritic cells |
| title_full |
How helminths use excretory secretory fractions to modulate dendritic cells |
| title_fullStr |
How helminths use excretory secretory fractions to modulate dendritic cells |
| title_full_unstemmed |
How helminths use excretory secretory fractions to modulate dendritic cells |
| title_sort |
how helminths use excretory secretory fractions to modulate dendritic cells |
| description |
It is well known that helminth parasites have immunomodulatory effects on their hosts. They characteristically cause a skew toward TH2 immunity, stimulate Treg cells while simultaneously inhibiting TH1 and TH17 responses. Additionally, they induce eosinophilia and extensive IgE release. The exact mechanism of how the worms achieve this effect have yet to be fully elucidated; however, parasite-derived secretions and their interaction with antigen presenting cells have been centrally implicated. Herein, we will review the effects of helminth excretory-secretory fractions on dendritic cells and discuss how this interaction is crucial in shaping the host response. |
| publisher |
Landes Bioscience |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545949/ |
| _version_ |
1611947199282806784 |