Aminoglycosylation Can Enhance the G-Quadruplex Binding Activity of Epigallocatechin

With the aim of enhancing G-quadruplex binding activity, two new glucosaminosides (16, 18) of penta-methylated epigallocatechin were synthesized by chemical glycosylation. Subsequent ESI-TOF-MS analysis demonstrated that these two glucosaminoside derivatives exhibit much stronger binding activity to...

Full description

Bibliographic Details
Main Authors: Bai, Li-Ping, Ho, Hing-Man, Ma, Dik-Lung, Yang, Hui, Fu, Wai-Chung, Jiang, Zhi-Hong
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545880/