Increased active von Willebrand factor during disease development in the aging diabetic patient population
Type 2 diabetes is known to cause endothelial activation resulting in the secretion of von Willebrand factor (VWF). We have shown that levels of VWF in a glycoprotein Ib-binding conformation are increased in specific clinical settings. The aim of the current study is to investigate whether active VW...
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Springer Netherlands
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543747/ |
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pubmed-35437472013-01-14 Increased active von Willebrand factor during disease development in the aging diabetic patient population Chen, Shuang Feng Xia, Zuo Li Han, Ji Ju Wang, Yi Ting Wang, Ji Yue Pan, Shao Dong Wu, Ya Ping Zhang, Bin Li, Guang Yao Du, Jing Wei Gao, Hen Qiang de Groot, Philip G. de Laat, Bas Hollestelle, Martine J. Article Type 2 diabetes is known to cause endothelial activation resulting in the secretion of von Willebrand factor (VWF). We have shown that levels of VWF in a glycoprotein Ib-binding conformation are increased in specific clinical settings. The aim of the current study is to investigate whether active VWF levels increase during aging and the development of diabetes within the population of patients suffering from type 2 diabetes. Patients and controls were divided into two groups based on age: older and younger than 60 years of age. VWF antigen, VWF propeptide, VWF activation factor and total active VWF were measured. Patients older than 60 years of age had increased levels of total active VWF, VWF activation factor and VWF propeptide compared to younger patients and controls. All measured VWF parameters were associated with age in diabetic patients. Total active VWF and VWF propeptide correlated with the period of being diagnosed with diabetes. Regression analyses showed that especially the VWF activation factor was strongly associated with diabetes in patients older than 60 years of age. In conclusion, we found that the conformation of VWF could be involved in the disease process of diabetes and that the VWF in a glycoprotein Ib-binding conformation could play a role as risk marker during the development of diabetes in combination with an increase in age. Our study shows that the active quality of VWF was more important than the quantity. Springer Netherlands 2011-11-27 2013-02 /pmc/articles/PMC3543747/ /pubmed/22120183 http://dx.doi.org/10.1007/s11357-011-9335-0 Text en © The Author(s) 2011 |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Chen, Shuang Feng Xia, Zuo Li Han, Ji Ju Wang, Yi Ting Wang, Ji Yue Pan, Shao Dong Wu, Ya Ping Zhang, Bin Li, Guang Yao Du, Jing Wei Gao, Hen Qiang de Groot, Philip G. de Laat, Bas Hollestelle, Martine J. |
| spellingShingle |
Chen, Shuang Feng Xia, Zuo Li Han, Ji Ju Wang, Yi Ting Wang, Ji Yue Pan, Shao Dong Wu, Ya Ping Zhang, Bin Li, Guang Yao Du, Jing Wei Gao, Hen Qiang de Groot, Philip G. de Laat, Bas Hollestelle, Martine J. Increased active von Willebrand factor during disease development in the aging diabetic patient population |
| author_facet |
Chen, Shuang Feng Xia, Zuo Li Han, Ji Ju Wang, Yi Ting Wang, Ji Yue Pan, Shao Dong Wu, Ya Ping Zhang, Bin Li, Guang Yao Du, Jing Wei Gao, Hen Qiang de Groot, Philip G. de Laat, Bas Hollestelle, Martine J. |
| author_sort |
Chen, Shuang Feng |
| title |
Increased active von Willebrand factor during disease development in the aging diabetic patient population |
| title_short |
Increased active von Willebrand factor during disease development in the aging diabetic patient population |
| title_full |
Increased active von Willebrand factor during disease development in the aging diabetic patient population |
| title_fullStr |
Increased active von Willebrand factor during disease development in the aging diabetic patient population |
| title_full_unstemmed |
Increased active von Willebrand factor during disease development in the aging diabetic patient population |
| title_sort |
increased active von willebrand factor during disease development in the aging diabetic patient population |
| description |
Type 2 diabetes is known to cause endothelial activation resulting in the secretion of von Willebrand factor (VWF). We have shown that levels of VWF in a glycoprotein Ib-binding conformation are increased in specific clinical settings. The aim of the current study is to investigate whether active VWF levels increase during aging and the development of diabetes within the population of patients suffering from type 2 diabetes. Patients and controls were divided into two groups based on age: older and younger than 60 years of age. VWF antigen, VWF propeptide, VWF activation factor and total active VWF were measured. Patients older than 60 years of age had increased levels of total active VWF, VWF activation factor and VWF propeptide compared to younger patients and controls. All measured VWF parameters were associated with age in diabetic patients. Total active VWF and VWF propeptide correlated with the period of being diagnosed with diabetes. Regression analyses showed that especially the VWF activation factor was strongly associated with diabetes in patients older than 60 years of age. In conclusion, we found that the conformation of VWF could be involved in the disease process of diabetes and that the VWF in a glycoprotein Ib-binding conformation could play a role as risk marker during the development of diabetes in combination with an increase in age. Our study shows that the active quality of VWF was more important than the quantity. |
| publisher |
Springer Netherlands |
| publishDate |
2011 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543747/ |
| _version_ |
1611946574791835648 |