Cleavage of von Willebrand Factor by Granzyme M Destroys Its Factor VIII Binding Capacity

Cleavage of von Willebrand Factor by Granzyme M Destroys Its Factor VIII Binding Capacity

Von Willebrand factor (VWF) is a pro-hemostatic multimeric plasma protein that promotes platelet aggregation and stabilizes coagulation factor VIII (FVIII) in plasma. The metalloproteinase ADAMTS13 regulates the platelet aggregation function of VWF via proteolysis. Severe deficiency of ADAMTS13 is a...

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Bibliographic Details
Main Authors: Hollestelle, Martine J., Lai, Ka Wai, van Deuren, Marcel, Lenting, Peter J., de Groot, Philip G., Sprong, Tom, Bovenschen, Niels
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164717/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164717/

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