Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells

Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells

The generation of induced pluripotent stem cells (iPSCs) often results in aberrant epigenetic silencing of the imprinted Dlk1-Dio3 gene cluster, which compromises the cells’ ability to generate entirely iPSC-derived adult mice (“all-iPSC mice”). Here, we show that reprogramming in the presence of as...

Full description

Bibliographic Details
Main Authors: Stadtfeld, Matthias, Apostolou, Effie, Ferrari, Francesco, Choi, Jiho, Walsh, Ryan M., Chen, Taiping, Oi, Steen, Kim, Sang Yong, Bestor, Tim, Shioda, Toshi, Park, Peter J., Hochedlinger, Konrad
Format: Online
Language:English
Published: 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538378/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538378/

Similar Items