A full-length recombinant Plasmodium falciparum PfRH5 protein induces inhibitory antibodies that are effective across common PfRH5 genetic variants

► PfRH5 is essential for Plasmodium falciparum erythrocyte invasion. ► Antibodies raised against full-length functional PfRH5 potently blocked invasion. ► Five common PfRH5 polymorphisms were identified across 290 clinical isolates. ► Antibodies raised against one variant inhibited all other common...

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Main Authors:	Bustamante, Leyla Y., Bartholdson, S. Josefin, Crosnier, Cecile, Campos, Marta G., Wanaguru, Madushi, Nguon, Chea, Kwiatkowski, Dominic P., Wright, Gavin J., Rayner, Julian C.
Format:	Online
Language:	English
Published:	Elsevier Science 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538003/

id	pubmed-3538003
recordtype	oai_dc
spelling	pubmed-35380032013-01-08 A full-length recombinant Plasmodium falciparum PfRH5 protein induces inhibitory antibodies that are effective across common PfRH5 genetic variants Bustamante, Leyla Y. Bartholdson, S. Josefin Crosnier, Cecile Campos, Marta G. Wanaguru, Madushi Nguon, Chea Kwiatkowski, Dominic P. Wright, Gavin J. Rayner, Julian C. Article ► PfRH5 is essential for Plasmodium falciparum erythrocyte invasion. ► Antibodies raised against full-length functional PfRH5 potently blocked invasion. ► Five common PfRH5 polymorphisms were identified across 290 clinical isolates. ► Antibodies raised against one variant inhibited all other common PfRH5 variants. ► Correctly folded recombinant PfRH5 is a strong P. falciparum vaccine candidate. Elsevier Science 2013-01-02 /pmc/articles/PMC3538003/ /pubmed/23146673 http://dx.doi.org/10.1016/j.vaccine.2012.10.106 Text en © 2013 Elsevier Ltd. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Bustamante, Leyla Y. Bartholdson, S. Josefin Crosnier, Cecile Campos, Marta G. Wanaguru, Madushi Nguon, Chea Kwiatkowski, Dominic P. Wright, Gavin J. Rayner, Julian C.
spellingShingle	Bustamante, Leyla Y. Bartholdson, S. Josefin Crosnier, Cecile Campos, Marta G. Wanaguru, Madushi Nguon, Chea Kwiatkowski, Dominic P. Wright, Gavin J. Rayner, Julian C. A full-length recombinant Plasmodium falciparum PfRH5 protein induces inhibitory antibodies that are effective across common PfRH5 genetic variants
author_facet	Bustamante, Leyla Y. Bartholdson, S. Josefin Crosnier, Cecile Campos, Marta G. Wanaguru, Madushi Nguon, Chea Kwiatkowski, Dominic P. Wright, Gavin J. Rayner, Julian C.
author_sort	Bustamante, Leyla Y.
title	A full-length recombinant Plasmodium falciparum PfRH5 protein induces inhibitory antibodies that are effective across common PfRH5 genetic variants
title_short	A full-length recombinant Plasmodium falciparum PfRH5 protein induces inhibitory antibodies that are effective across common PfRH5 genetic variants
title_full	A full-length recombinant Plasmodium falciparum PfRH5 protein induces inhibitory antibodies that are effective across common PfRH5 genetic variants
title_fullStr	A full-length recombinant Plasmodium falciparum PfRH5 protein induces inhibitory antibodies that are effective across common PfRH5 genetic variants
title_full_unstemmed	A full-length recombinant Plasmodium falciparum PfRH5 protein induces inhibitory antibodies that are effective across common PfRH5 genetic variants
title_sort	full-length recombinant plasmodium falciparum pfrh5 protein induces inhibitory antibodies that are effective across common pfrh5 genetic variants
description	► PfRH5 is essential for Plasmodium falciparum erythrocyte invasion. ► Antibodies raised against full-length functional PfRH5 potently blocked invasion. ► Five common PfRH5 polymorphisms were identified across 290 clinical isolates. ► Antibodies raised against one variant inhibited all other common PfRH5 variants. ► Correctly folded recombinant PfRH5 is a strong P. falciparum vaccine candidate.
publisher	Elsevier Science
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538003/
_version_	1611944795504115712

A full-length recombinant Plasmodium falciparum PfRH5 protein induces inhibitory antibodies that are effective across common PfRH5 genetic variants

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