High Expression of the Pi-Transporter SLC20A1/Pit1 in Calcific Aortic Valve Disease Promotes Mineralization through Regulation of Akt-1

High Expression of the Pi-Transporter SLC20A1/Pit1 in Calcific Aortic Valve Disease Promotes Mineralization through Regulation of Akt-1

The regulation of phosphate (Pi) handling is crucial during calcification of the aortic valve. Gene profiling of Pi transporters revealed that VIC culture expresses SLC201A1/Pit1 and SLC20A2/Pit2. On exposure to a mineralizing medium (2 mM Pi), the expression of Pi transporters in VIC culture is inc...

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Bibliographic Details
Main Authors: El Husseini, Diala, Boulanger, Marie-Chloé, Fournier, Dominique, Mahmut, Ablajan, Bossé, Yohan, Pibarot, Philippe, Mathieu, Patrick
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537628/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537628/

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