Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response

Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response

In senescent cells, a DNA damage response drives not only irreversible loss of replicative capacity but also production and secretion of reactive oxygen species (ROS) and bioactive peptides including pro-inflammatory cytokines. This makes senescent cells a potential cause of tissue functional declin...

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Bibliographic Details
Main Authors: Jurk, Diana, Wang, Chunfang, Miwa, Satomi, Maddick, Mandy, Korolchuk, Viktor, Tsolou, Avgi, Gonos, Efstathios S, Thrasivoulou, Christopher, Jill Saffrey, M, Cameron, Kerry, von Zglinicki, Thomas
Format: Online
Language:English
Published: Blackwell Publishing Ltd 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533793/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533793/

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