A senescent cell bystander effect: senescence-induced senescence

Senescent cells produce and secrete various bioactive molecules including interleukins, growth factors, matrix-degrading enzymes and reactive oxygen species (ROS). Thus, it has been proposed that senescent cells can damage their local environment, and a stimulatory effect on tumour cell growth and i...

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Bibliographic Details
Main Authors: Nelson, Glyn, Wordsworth, James, Wang, Chunfang, Jurk, Diana, Lawless, Conor, Martin-Ruiz, Carmen, von Zglinicki, Thomas
Format: Online
Language:English
Published: Blackwell Publishing Ltd 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488292/