Influence of Pentraxin 3 (PTX3) Genetic Variants on Myocardial Infarction Risk and PTX3 Plasma Levels
PTX3 is a long pentraxin of the innate immune system produced by different cell types (mononuclear phagocytes, dendritic cells, fibroblasts and endothelial cells) at the inflammatory site. It appears to have a cardiovascular protective function by acting on the immune-inflammatory balance in the car...
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Public Library of Science
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532160/ |
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pubmed-35321602013-01-02 Influence of Pentraxin 3 (PTX3) Genetic Variants on Myocardial Infarction Risk and PTX3 Plasma Levels Barbati, Elisa Specchia, Claudia Villella, Massimo Rossi, Marco Luciano Barlera, Simona Bottazzi, Barbara Crociati, Luisa d’Arienzo, Carmela Fanelli, Raffaele Garlanda, Cecilia Gori, Francesca Mango, Ruggiero Mantovani, Alberto Merla, Giuseppe Nicolis, Enrico B. Pietri, Silvia Presbitero, Patrizia Sudo, Yukio Villella, Alessandro Franzosi, Maria Grazia Research Article PTX3 is a long pentraxin of the innate immune system produced by different cell types (mononuclear phagocytes, dendritic cells, fibroblasts and endothelial cells) at the inflammatory site. It appears to have a cardiovascular protective function by acting on the immune-inflammatory balance in the cardiovascular system. PTX3 plasma concentration is an independent predictor of mortality in patients with acute myocardial infarction (AMI) but the influence of PTX3 genetic variants on PTX3 plasma concentration has been investigated very little and there is no information on the association between PTX3 variations and AMI. Subjects of European origin (3245, 1751 AMI survivors and 1494 controls) were genotyped for three common PTX3 polymorphisms (SNPs) (rs2305619, rs3816527, rs1840680). Genotype and allele frequencies of the three SNPs and the haplotype frequencies were compared for the two groups. None of the genotypes, alleles or haplotypes were significantly associated with the risk of AMI. However, analysis adjusted for age and sex indicated that the three PTX3 SNPs and the corresponding haplotypes were significantly associated with different PTX3 plasma levels. There was also a significant association between PTX3 plasma concentrations and the risk of all-cause mortality at three years in AMI patients (OR 1.10, 95% CI: 1.01–1.20, p = 0.02). Our study showed that PTX3 plasma levels are influenced by three PTX3 polymorphisms. Genetically determined high PTX3 levels do not influence the risk of AMI, suggesting that the PTX3 concentration itself is unlikely to be even a modest causal factor for AMI. Analysis also confirmed that PTX3 is a prognostic marker after AMI. Public Library of Science 2012-12-28 /pmc/articles/PMC3532160/ /pubmed/23285251 http://dx.doi.org/10.1371/journal.pone.0053030 Text en © 2012 Barbati et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Barbati, Elisa Specchia, Claudia Villella, Massimo Rossi, Marco Luciano Barlera, Simona Bottazzi, Barbara Crociati, Luisa d’Arienzo, Carmela Fanelli, Raffaele Garlanda, Cecilia Gori, Francesca Mango, Ruggiero Mantovani, Alberto Merla, Giuseppe Nicolis, Enrico B. Pietri, Silvia Presbitero, Patrizia Sudo, Yukio Villella, Alessandro Franzosi, Maria Grazia |
| spellingShingle |
Barbati, Elisa Specchia, Claudia Villella, Massimo Rossi, Marco Luciano Barlera, Simona Bottazzi, Barbara Crociati, Luisa d’Arienzo, Carmela Fanelli, Raffaele Garlanda, Cecilia Gori, Francesca Mango, Ruggiero Mantovani, Alberto Merla, Giuseppe Nicolis, Enrico B. Pietri, Silvia Presbitero, Patrizia Sudo, Yukio Villella, Alessandro Franzosi, Maria Grazia Influence of Pentraxin 3 (PTX3) Genetic Variants on Myocardial Infarction Risk and PTX3 Plasma Levels |
| author_facet |
Barbati, Elisa Specchia, Claudia Villella, Massimo Rossi, Marco Luciano Barlera, Simona Bottazzi, Barbara Crociati, Luisa d’Arienzo, Carmela Fanelli, Raffaele Garlanda, Cecilia Gori, Francesca Mango, Ruggiero Mantovani, Alberto Merla, Giuseppe Nicolis, Enrico B. Pietri, Silvia Presbitero, Patrizia Sudo, Yukio Villella, Alessandro Franzosi, Maria Grazia |
| author_sort |
Barbati, Elisa |
| title |
Influence of Pentraxin 3 (PTX3) Genetic Variants on Myocardial Infarction Risk and PTX3 Plasma Levels |
| title_short |
Influence of Pentraxin 3 (PTX3) Genetic Variants on Myocardial Infarction Risk and PTX3 Plasma Levels |
| title_full |
Influence of Pentraxin 3 (PTX3) Genetic Variants on Myocardial Infarction Risk and PTX3 Plasma Levels |
| title_fullStr |
Influence of Pentraxin 3 (PTX3) Genetic Variants on Myocardial Infarction Risk and PTX3 Plasma Levels |
| title_full_unstemmed |
Influence of Pentraxin 3 (PTX3) Genetic Variants on Myocardial Infarction Risk and PTX3 Plasma Levels |
| title_sort |
influence of pentraxin 3 (ptx3) genetic variants on myocardial infarction risk and ptx3 plasma levels |
| description |
PTX3 is a long pentraxin of the innate immune system produced by different cell types (mononuclear phagocytes, dendritic cells, fibroblasts and endothelial cells) at the inflammatory site. It appears to have a cardiovascular protective function by acting on the immune-inflammatory balance in the cardiovascular system. PTX3 plasma concentration is an independent predictor of mortality in patients with acute myocardial infarction (AMI) but the influence of PTX3 genetic variants on PTX3 plasma concentration has been investigated very little and there is no information on the association between PTX3 variations and AMI. Subjects of European origin (3245, 1751 AMI survivors and 1494 controls) were genotyped for three common PTX3 polymorphisms (SNPs) (rs2305619, rs3816527, rs1840680). Genotype and allele frequencies of the three SNPs and the haplotype frequencies were compared for the two groups. None of the genotypes, alleles or haplotypes were significantly associated with the risk of AMI. However, analysis adjusted for age and sex indicated that the three PTX3 SNPs and the corresponding haplotypes were significantly associated with different PTX3 plasma levels. There was also a significant association between PTX3 plasma concentrations and the risk of all-cause mortality at three years in AMI patients (OR 1.10, 95% CI: 1.01–1.20, p = 0.02). Our study showed that PTX3 plasma levels are influenced by three PTX3 polymorphisms. Genetically determined high PTX3 levels do not influence the risk of AMI, suggesting that the PTX3 concentration itself is unlikely to be even a modest causal factor for AMI. Analysis also confirmed that PTX3 is a prognostic marker after AMI. |
| publisher |
Public Library of Science |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532160/ |
| _version_ |
1611943319177265152 |