Binding of ATP at the active site of human pancreatic glucokinase – nucleotide-induced conformational changes with possible implications for its kinetic cooperativity
Glucokinase (GK) is the central player in glucose-stimulated insulin release from pancreatic β-cells, and catalytic activation by α-d-glucose binding has a key regulatory function. Whereas the mechanism of this activation is well understood, on the basis of crystal structures of human GK, there are...
| Main Authors: | , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Blackwell Publishing Ltd
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531626/ |