The E3 SUMO ligase PIASγ is a novel interaction partner regulating the activity of diabetes associated hepatocyte nuclear factor-1α

The E3 SUMO ligase PIASγ is a novel interaction partner regulating the activity of diabetes associated hepatocyte nuclear factor-1α

Abstract The transcription factor hepatocyte nuclear factor-1α (HNF-1A) is involved in normal pancreas development and function. Rare variants in the HNF1A gene can cause monogenic diabetes, while common variants confer type 2 diabetes risk. The precise mechanisms for regulation of HNF-1A, including...

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Bibliographic Details
Main Authors: Alba Kaci, Magdalena Keindl, Marie H. Solheim, Pål R. Njølstad, Lise Bjørkhaug, Ingvild Aukrust
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Scientific Reports
Online Access:http://link.springer.com/article/10.1038/s41598-018-29448-w

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http://link.springer.com/article/10.1038/s41598-018-29448-w

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