MiniCD4 Microbicide Prevents HIV Infection of Human Mucosal Explants and Vaginal Transmission of SHIV162P3 in Cynomolgus Macaques

MiniCD4 Microbicide Prevents HIV Infection of Human Mucosal Explants and Vaginal Transmission of SHIV162P3 in Cynomolgus Macaques

In complement to an effective vaccine, development of potent anti-HIV microbicides remains an important priority. We have previously shown that the miniCD4 M48U1, a functional mimetic of sCD4 presented on a 27 amino-acid stable scaffold, inhibits a broad range of HIV-1 isolates at sub-nanomolar conc...

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Bibliographic Details
Main Authors: Dereuddre-Bosquet, Nathalie, Morellato-Castillo, Laurence, Brouwers, Joachim, Augustijns, Patrick, Bouchemal, Kawthar, Ponchel, Gilles, Ramos, Oscar H. P., Herrera, Carolina, Stefanidou, Martha, Shattock, Robin, Heyndrickx, Leo, Vanham, Guido, Kessler, Pascal, Le Grand, Roger, Martin, Loïc
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516572/

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