CD4-mimetic sulfopeptide conjugates display sub-nanomolar anti-HIV-1 activity and protect macaques against a SHIV162P3 vaginal challenge

CD4-mimetic sulfopeptide conjugates display sub-nanomolar anti-HIV-1 activity and protect macaques against a SHIV162P3 vaginal challenge

The CD4 and the cryptic coreceptor binding sites of the HIV-1 envelope glycoprotein are key to viral attachment and entry. We developed new molecules comprising a CD4 mimetic peptide linked to anionic compounds (mCD4.1-HS12 and mCD4.1-PS1), that block the CD4-gp120 interaction and simultaneously ind...

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Bibliographic Details
Main Authors: Ariën, Kevin K., Baleux, Françoise, Desjardins, Delphine, Porrot, Françoise, Coïc, Yves-Marie, Michiels, Johan, Bouchemal, Kawthar, Bonnaffé, David, Bruel, Timothée, Schwartz, Olivier, Le Grand, Roger, Vanham, Guido, Dereuddre-Bosquet, Nathalie, Lortat-Jacob, Hugues
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056392/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056392/

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