The Hedgehog signalling pathway regulates autophagy

Autophagy is a highly conserved degradative process that removes damaged or unnecessary proteins and organelles, and recycles cytoplasmic contents during starvation. Autophagy is essential in physiological processes such as embryonic development but how autophagy is regulated by canonical developmen...

Full description

Bibliographic Details
Main Authors:	Jimenez-Sanchez, Maria, Menzies, Fiona M., Chang, Yu-Yun, Simecek, Nikol, Neufeld, Thomas P., Rubinsztein, David C.
Format:	Online
Language:	English
Published:	Nature Pub. Group 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514496/

id	pubmed-3514496
recordtype	oai_dc
spelling	pubmed-35144962012-12-05 The Hedgehog signalling pathway regulates autophagy Jimenez-Sanchez, Maria Menzies, Fiona M. Chang, Yu-Yun Simecek, Nikol Neufeld, Thomas P. Rubinsztein, David C. Article Autophagy is a highly conserved degradative process that removes damaged or unnecessary proteins and organelles, and recycles cytoplasmic contents during starvation. Autophagy is essential in physiological processes such as embryonic development but how autophagy is regulated by canonical developmental pathways is unclear. Here we show that the Hedgehog signalling pathway inhibits autophagosome synthesis, both in basal and in autophagy-induced conditions. This mechanism is conserved in mammalian cells and in Drosophila, and requires the orthologous transcription factors Gli2 and Ci, respectively. Furthermore, we identify that activation of the Hedgehog pathway reduces PERK levels, concomitant with a decrease in phosphorylation of the translation initiation factor eukaryotic initiation factor 2α, suggesting a novel target of this pathway and providing a possible link between Hedgehog signalling and autophagy. Nature Pub. Group 2012-11-13 /pmc/articles/PMC3514496/ /pubmed/23149744 http://dx.doi.org/10.1038/ncomms2212 Text en Copyright © 2012, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Jimenez-Sanchez, Maria Menzies, Fiona M. Chang, Yu-Yun Simecek, Nikol Neufeld, Thomas P. Rubinsztein, David C.
spellingShingle	Jimenez-Sanchez, Maria Menzies, Fiona M. Chang, Yu-Yun Simecek, Nikol Neufeld, Thomas P. Rubinsztein, David C. The Hedgehog signalling pathway regulates autophagy
author_facet	Jimenez-Sanchez, Maria Menzies, Fiona M. Chang, Yu-Yun Simecek, Nikol Neufeld, Thomas P. Rubinsztein, David C.
author_sort	Jimenez-Sanchez, Maria
title	The Hedgehog signalling pathway regulates autophagy
title_short	The Hedgehog signalling pathway regulates autophagy
title_full	The Hedgehog signalling pathway regulates autophagy
title_fullStr	The Hedgehog signalling pathway regulates autophagy
title_full_unstemmed	The Hedgehog signalling pathway regulates autophagy
title_sort	hedgehog signalling pathway regulates autophagy
description	Autophagy is a highly conserved degradative process that removes damaged or unnecessary proteins and organelles, and recycles cytoplasmic contents during starvation. Autophagy is essential in physiological processes such as embryonic development but how autophagy is regulated by canonical developmental pathways is unclear. Here we show that the Hedgehog signalling pathway inhibits autophagosome synthesis, both in basal and in autophagy-induced conditions. This mechanism is conserved in mammalian cells and in Drosophila, and requires the orthologous transcription factors Gli2 and Ci, respectively. Furthermore, we identify that activation of the Hedgehog pathway reduces PERK levels, concomitant with a decrease in phosphorylation of the translation initiation factor eukaryotic initiation factor 2α, suggesting a novel target of this pathway and providing a possible link between Hedgehog signalling and autophagy.
publisher	Nature Pub. Group
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514496/
_version_	1611938105266274304

The Hedgehog signalling pathway regulates autophagy

Similar Items