Autophagy and polyglutamine diseases

► The ubiquitin–proteasome system and autophagy are two main degradative pathways. ► Autophagy upregulation may protect against polyglutamine-expanded protein neurotoxicity. ► Autophagy compromise may occur in certain neurodegenerative diseases.

Bibliographic Details
Main Authors: Jimenez-Sanchez, Maria, Thomson, Frances, Zavodszky, Eszter, Rubinsztein, David C.
Format: Online
Language:English
Published: Pergamon Press 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712188/