Assessment of Genotype Imputation Performance Using 1000 Genomes in African American Studies

Assessment of Genotype Imputation Performance Using 1000 Genomes in African American Studies

Genotype imputation, used in genome-wide association studies to expand coverage of single nucleotide polymorphisms (SNPs), has performed poorly in African Americans compared to less admixed populations. Overall, imputation has typically relied on HapMap reference haplotype panels from Africans (YRI)...

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Bibliographic Details
Main Authors: Hancock, Dana B., Levy, Joshua L., Gaddis, Nathan C., Bierut, Laura J., Saccone, Nancy L., Page, Grier P., Johnson, Eric O.
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511547/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511547/

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