Effect of particle size on solubility, dissolution rate, and oral bioavailability: evaluation using coenzyme Q10 as naked nanocrystals
In this paper work, four naked nanocrystals (size range 80–700 nm) were prepared without any surfactant or polymer using the solvent/nonsolvent method. The effects of particle size on their solubility, dissolution, and oral bioavailability were investigated. Solubility and dissolution testing were p...
| Main Authors: | , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Dove Medical Press
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500035/ |