Differential Regulation of Amyloid Precursor Protein/Presenilin 1 Interaction during Ab40/42 Production Detected Using Fusion Constructs

Differential Regulation of Amyloid Precursor Protein/Presenilin 1 Interaction during Ab40/42 Production Detected Using Fusion Constructs

Beta amyloid peptides (Aβ) play a key role in the pathogenesis of Alzheimer disease (AD). Presenilins (PS) function as the catalytic subunits of γ-secretase, the enzyme that releases Aβ from ectodomain cleaved amyloid precursor protein (APP) by intramembrane proteolysis. Familial Alzheimer disease (...

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Bibliographic Details
Main Authors: Sato, Naoyuki, Okochi, Masayasu, Shinohara, Mitsuru, Thinakaran, Gopal, Takeda, Shuko, Fukumori, Akio, Shinohara-Noma, Motoko, Mori-Ueda, Mari, Hamada, Hizuki, Takeda, Masatoshi, Rakugi, Hiromi, Morishita, Ryuichi
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495957/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495957/

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