Protective Effects of Fluoxetine on Decompression Sickness in Mice

Massive bubble formation after diving can lead to decompression sickness (DCS) that can result in central nervous system disorders or even death. Bubbles alter the vascular endothelium and activate blood cells and inflammatory pathways, leading to a systemic pathophysiological process that promotes...

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Main Authors:	Blatteau, Jean-Eric, Barre, Sandrine, Pascual, Aurelie, Castagna, Olivier, Abraini, Jacques H., Risso, Jean-Jacques, Vallee, Nicolas
Format:	Online
Language:	English
Published:	Public Library of Science 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493517/

id	pubmed-3493517
recordtype	oai_dc
spelling	pubmed-34935172012-11-09 Protective Effects of Fluoxetine on Decompression Sickness in Mice Blatteau, Jean-Eric Barre, Sandrine Pascual, Aurelie Castagna, Olivier Abraini, Jacques H. Risso, Jean-Jacques Vallee, Nicolas Research Article Massive bubble formation after diving can lead to decompression sickness (DCS) that can result in central nervous system disorders or even death. Bubbles alter the vascular endothelium and activate blood cells and inflammatory pathways, leading to a systemic pathophysiological process that promotes ischemic damage. Fluoxetine, a well-known antidepressant, is recognized as having anti-inflammatory properties at the systemic level, as well as in the setting of cerebral ischemia. We report a beneficial clinical effect associated with fluoxetine in experimental DCS. 91 mice were subjected to a simulated dive at 90 msw for 45 min before rapid decompression. The experimental group received 50 mg/kg of fluoxetine 18 hours before hyperbaric exposure (n = 46) while controls were not treated (n = 45). Clinical assessment took place over a period of 30 min after surfacing. At the end, blood samples were collected for blood cells counts and cytokine IL-6 detection. There were significantly fewer manifestations of DCS in the fluoxetine group than in the controls (43.5% versus 75.5%, respectively; p = 0.004). Survivors showed a better and significant neurological recovery with fluoxetine. Platelets and red cells were significantly decreased after decompression in controls but not in the treated mice. Fluoxetine reduced circulating IL-6, a relevant marker of systemic inflammation in DCS. We concluded that fluoxetine decreased the incidence of DCS and improved motor recovery, by limiting inflammation processes. Public Library of Science 2012-11-08 /pmc/articles/PMC3493517/ /pubmed/23145072 http://dx.doi.org/10.1371/journal.pone.0049069 Text en © 2012 Blatteau et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Blatteau, Jean-Eric Barre, Sandrine Pascual, Aurelie Castagna, Olivier Abraini, Jacques H. Risso, Jean-Jacques Vallee, Nicolas
spellingShingle	Blatteau, Jean-Eric Barre, Sandrine Pascual, Aurelie Castagna, Olivier Abraini, Jacques H. Risso, Jean-Jacques Vallee, Nicolas Protective Effects of Fluoxetine on Decompression Sickness in Mice
author_facet	Blatteau, Jean-Eric Barre, Sandrine Pascual, Aurelie Castagna, Olivier Abraini, Jacques H. Risso, Jean-Jacques Vallee, Nicolas
author_sort	Blatteau, Jean-Eric
title	Protective Effects of Fluoxetine on Decompression Sickness in Mice
title_short	Protective Effects of Fluoxetine on Decompression Sickness in Mice
title_full	Protective Effects of Fluoxetine on Decompression Sickness in Mice
title_fullStr	Protective Effects of Fluoxetine on Decompression Sickness in Mice
title_full_unstemmed	Protective Effects of Fluoxetine on Decompression Sickness in Mice
title_sort	protective effects of fluoxetine on decompression sickness in mice
description	Massive bubble formation after diving can lead to decompression sickness (DCS) that can result in central nervous system disorders or even death. Bubbles alter the vascular endothelium and activate blood cells and inflammatory pathways, leading to a systemic pathophysiological process that promotes ischemic damage. Fluoxetine, a well-known antidepressant, is recognized as having anti-inflammatory properties at the systemic level, as well as in the setting of cerebral ischemia. We report a beneficial clinical effect associated with fluoxetine in experimental DCS. 91 mice were subjected to a simulated dive at 90 msw for 45 min before rapid decompression. The experimental group received 50 mg/kg of fluoxetine 18 hours before hyperbaric exposure (n = 46) while controls were not treated (n = 45). Clinical assessment took place over a period of 30 min after surfacing. At the end, blood samples were collected for blood cells counts and cytokine IL-6 detection. There were significantly fewer manifestations of DCS in the fluoxetine group than in the controls (43.5% versus 75.5%, respectively; p = 0.004). Survivors showed a better and significant neurological recovery with fluoxetine. Platelets and red cells were significantly decreased after decompression in controls but not in the treated mice. Fluoxetine reduced circulating IL-6, a relevant marker of systemic inflammation in DCS. We concluded that fluoxetine decreased the incidence of DCS and improved motor recovery, by limiting inflammation processes.
publisher	Public Library of Science
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493517/
_version_	1611922843001421824

Protective Effects of Fluoxetine on Decompression Sickness in Mice

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