Silencing of the polyamine catabolic key enzyme SSAT prevents CDK inhibitor-induced apoptosis in Caco-2 colon cancer cells
Roscovitine and purvalanol are purine derivative cyclin-dependent kinase (CDK) inhibitors that induce apoptosis in various types of cancer cells. However, their impact on the apoptotic cell death mechanism requires further elucidation. Natural polyamines putrescine, spermidine and spermine play esse...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
D.A. Spandidos
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493106/ |