The early antitumor immune response is necessary for tumor growth: Re-visiting Prehn’s hypothesis in the human melanoma system

Early events responsible of tumor growth in patients with a normal immune system are poorly understood. Here, we discuss, in the context of human melanoma, the Prehn hypothesis according to which a weak antitumor immune response may be required for tumor growth before weakly or non-immunogenic tumo...

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Main Authors:	Parmiani, Giorgio, Maccalli, Cristina
Format:	Online
Language:	English
Published:	Landes Bioscience 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489749/

id	pubmed-3489749
recordtype	oai_dc
spelling	pubmed-34897492012-11-16 The early antitumor immune response is necessary for tumor growth: Re-visiting Prehn’s hypothesis in the human melanoma system Parmiani, Giorgio Maccalli, Cristina Point of View Early events responsible of tumor growth in patients with a normal immune system are poorly understood. Here, we discuss, in the context of human melanoma, the Prehn hypothesis according to which a weak antitumor immune response may be required for tumor growth before weakly or non-immunogenic tumor cell subpopulations are selected by the immune system. Landes Bioscience 2012-09-01 /pmc/articles/PMC3489749/ /pubmed/23162761 http://dx.doi.org/10.4161/onci.21455 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Parmiani, Giorgio Maccalli, Cristina
spellingShingle	Parmiani, Giorgio Maccalli, Cristina The early antitumor immune response is necessary for tumor growth: Re-visiting Prehn’s hypothesis in the human melanoma system
author_facet	Parmiani, Giorgio Maccalli, Cristina
author_sort	Parmiani, Giorgio
title	The early antitumor immune response is necessary for tumor growth: Re-visiting Prehn’s hypothesis in the human melanoma system
title_short	The early antitumor immune response is necessary for tumor growth: Re-visiting Prehn’s hypothesis in the human melanoma system
title_full	The early antitumor immune response is necessary for tumor growth: Re-visiting Prehn’s hypothesis in the human melanoma system
title_fullStr	The early antitumor immune response is necessary for tumor growth: Re-visiting Prehn’s hypothesis in the human melanoma system
title_full_unstemmed	The early antitumor immune response is necessary for tumor growth: Re-visiting Prehn’s hypothesis in the human melanoma system
title_sort	early antitumor immune response is necessary for tumor growth: re-visiting prehn’s hypothesis in the human melanoma system
description	Early events responsible of tumor growth in patients with a normal immune system are poorly understood. Here, we discuss, in the context of human melanoma, the Prehn hypothesis according to which a weak antitumor immune response may be required for tumor growth before weakly or non-immunogenic tumor cell subpopulations are selected by the immune system.
publisher	Landes Bioscience
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489749/
_version_	1611921574118555648

The early antitumor immune response is necessary for tumor growth: Re-visiting Prehn’s hypothesis in the human melanoma system

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