Angiogenesis Inhibitor Vasohibin-1 Enhances Stress Resistance of Endothelial Cells via Induction of SOD2 and SIRT1

Angiogenesis Inhibitor Vasohibin-1 Enhances Stress Resistance of Endothelial Cells via Induction of SOD2 and SIRT1

Vasohibin-1 (VASH1) is isolated as an endothelial cell (EC)-produced angiogenesis inhibitor. We questioned whether VASH1 plays any role besides angiogenesis inhibition, knocked-down or overexpressed VASH1 in ECs, and examined the changes of EC property. Knock-down of VASH1 induced premature senescen...

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Bibliographic Details
Main Authors: Miyashita, Hiroki, Watanabe, Tatsuaki, Hayashi, Hideki, Suzuki, Yasuhiro, Nakamura, Takanobu, Ito, Soichi, Ono, Manabu, Hoshikawa, Yasushi, Okada, Yoshinori, Kondo, Takashi, Sato, Yasufumi
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466306/

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