Improvement in solubility of poor water-soluble drugs by solid dispersion
This article is intended to combine recent literature on solid dispersion technology for solubility enhancement with special emphasis on mechanism responsible for the same by solid dispersion, various preparation methods, and evaluation parameters. Solubility behavior is the most challenging aspect...
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| Format: | Online |
| Language: | English |
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Medknow Publications & Media Pvt Ltd
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465159/ |
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pubmed-34651592012-10-15 Improvement in solubility of poor water-soluble drugs by solid dispersion Sareen, Swati Mathew, George Joseph, Lincy Review Article This article is intended to combine recent literature on solid dispersion technology for solubility enhancement with special emphasis on mechanism responsible for the same by solid dispersion, various preparation methods, and evaluation parameters. Solubility behavior is the most challenging aspect for various new chemical entities as 60% of the new potential products possess solubility problems. This is the biggest reason for new drug molecules not reaching to the market or not reaches to full potential. There are various techniques to enhance the drug solubility such as particle size reduction, nanosuspension, use of surfactants, salt formation, solid dispersion, etc. From this article it may be concluded that solid dispersion is an important approach for improvement of bioavailability of poor water-soluble drugs. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3465159/ /pubmed/23071955 http://dx.doi.org/10.4103/2230-973X.96921 Text en Copyright: © International Journal of Pharmaceutical Investigation http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Sareen, Swati Mathew, George Joseph, Lincy |
| spellingShingle |
Sareen, Swati Mathew, George Joseph, Lincy Improvement in solubility of poor water-soluble drugs by solid dispersion |
| author_facet |
Sareen, Swati Mathew, George Joseph, Lincy |
| author_sort |
Sareen, Swati |
| title |
Improvement in solubility of poor water-soluble drugs by solid dispersion |
| title_short |
Improvement in solubility of poor water-soluble drugs by solid dispersion |
| title_full |
Improvement in solubility of poor water-soluble drugs by solid dispersion |
| title_fullStr |
Improvement in solubility of poor water-soluble drugs by solid dispersion |
| title_full_unstemmed |
Improvement in solubility of poor water-soluble drugs by solid dispersion |
| title_sort |
improvement in solubility of poor water-soluble drugs by solid dispersion |
| description |
This article is intended to combine recent literature on solid dispersion technology for solubility enhancement with special emphasis on mechanism responsible for the same by solid dispersion, various preparation methods, and evaluation parameters. Solubility behavior is the most challenging aspect for various new chemical entities as 60% of the new potential products possess solubility problems. This is the biggest reason for new drug molecules not reaching to the market or not reaches to full potential. There are various techniques to enhance the drug solubility such as particle size reduction, nanosuspension, use of surfactants, salt formation, solid dispersion, etc. From this article it may be concluded that solid dispersion is an important approach for improvement of bioavailability of poor water-soluble drugs. |
| publisher |
Medknow Publications & Media Pvt Ltd |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465159/ |
| _version_ |
1611914049278181376 |