HLA-B7–Restricted Islet Epitopes Are Differentially Recognized in Type 1 Diabetic Children and Adults and Form Weak Peptide-HLA Complexes

HLA-B7–Restricted Islet Epitopes Are Differentially Recognized in Type 1 Diabetic Children and Adults and Form Weak Peptide-HLA Complexes

The cartography of β-cell epitopes targeted by CD8+ T cells in type 1 diabetic (T1D) patients remains largely confined to the common HLA-A2 restriction. We aimed to identify β-cell epitopes restricted by the HLA-B7 (B*07:02) molecule, which is associated with mild T1D protection. Using DNA immunizat...

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Bibliographic Details
Main Authors: Scotto, Matthieu, Afonso, Georgia, Østerbye, Thomas, Larger, Etienne, Luce, Sandrine, Raverdy, Cécile, Novelli, Giulia, Bruno, Graziella, Gonfroy-Leymarie, Céline, Launay, Odile, Lemonnier, François A., Buus, Søren, Carel, Jean-Claude, Boitard, Christian, Mallone, Roberto
Format: Online
Language:English
Published: American Diabetes Association 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447897/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447897/

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